P0592RISK FACTORS FOR SEPSIS ASSCOCIATED-ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT PATIENTS

Abstract

Abstract Background and Aims To explore the risk factors of acute kidney injury in patients with sepsis in intensive care unit (ICU). Method The medical records of patients diagnosed with sepsis in ICU of west China hospital of Sichuan university from March 2009 to June 2016 were retrospectively analyzed. Differences between AKI group and Non-AKI group in general data, background disease, ICU entry and exit dates, complications, laboratory data and other related data were analyzed through univariate and multivariate statistical methods. Results A total of 2331 patients with sepsis were included in the study, including 626 patients in the AKI group and 1695 patients in the Non-AKI group. The multivariate logistic regression analysis confirmed that age >40 yr. [odds ratio (OR) =2.811], diabetes (OR=2.818), hypertension/coronary heart disease (OR=1.781), CKD (OR=13.221), the length of ICU stay ≥14 days (OR=3.327), heart failure (OR=2.316), ARDS (OR=2.105), SAP (OR=2.566), hypotension (OR=2.048), hypoproteinemia (OR=1.607), lactic acidosis (OR=2.380), hypoproteinemia (OR=1.607), organ failure >1 (OR=4.604),WBC > 10 ×109/L (OR=4.197), serum creatinine (OR=4.535), PCT (OR=1.808), Cys-C (OR=7.066), mild anemia (OR=2.321), moderate anemia (OR=4.047), and severe anemia (OR=6.100) were all independent risk factors of SA-AKI. Conclusion A variety of risk factors are related to the occurrence of SA-AKI. Early identification and monitoring of risk factors for SA-AKI and early prevention of AKI can improve the prognosis of sepsis patients.