P057 Measuring Patient-Reported Outcomes in Crohn's Disease Patients During the Outbreak of COVID-19

Abstract

BACKGROUND: There are no data regarding the application of Patient-Reported Outcome (PRO) measures under the COVID-19 pandemic. The aim of the present study was to use a specific PRO measuring tool in CD patients during the COVID-19 pandemic. METHODS: We interviewed 67 consecutive CD patients during the COVID-19 quarantine. We measured PROs using an adapted questionnaire that consists of a structured questionnaire evaluating 2 major domains: “symptoms” and “impacts”. In the “symptoms” domain, 4 sub-domains were evaluated, namely: “gastrointestinal”, “pain and discomfort”, “nutrition-related” and “energy-related”. In the “impacts” domain, 6 sub-domains were evaluated: “emotional”, “daily performance”, “lifestyle and activities”, “social functioning” and “dietary”. RESULTS: A total of 67 patients were interviewed. Mean age was 43.0 ± 14.7 years, 58.2% of patients were male. Mean disease duration was 12.4 ± 9.1 years, a history of perianal disease was present in 49.3% of patients, and 41.8% had previous bowel resection. There were no statistical differences in any of the 4 symptoms subdomains [“gastrointestinal” (P = 0.51), “pain and discomfort” (P = 0.08), “nutritional-related” (P = 0.97), and “energy-related” (P = 0.70)] when we compared active CD and patients in deep remission. There were no statistical differences in 4 of 6 subdomains [“daily performance” (P = 0.13), “lifestyle and activities” (P = 0.89), “social functioning” (P = 0.97), “dietary” (P = 0.34)]. Two out of 6 “impacts” sub-domain were significantly reduced in patients with clinical activity compared to patients in deep remission [Emotional (P = 0.04) and additional QoL (P = 0.01)]. CONCLUSION: The application of PRO measures in IBD patients demonstrated a negative impact on the emotional aspects and QoL quality of life during COVID-19 outbreak.