P05.08 * INTRACRANIAL IMMATURE TERATOMA WITH ANAPLASTIC CHANGE: A CASE REPORT

Abstract

Intracranial immature teratomas are rare tumor that categorized in the intermediate prognosis group. However, little is known about between their pathological feature and prognosis. In this case report, we describe a surgical case of immature teratoma located in the forth ventricle. CASE REPORT: A four months old girl presented with vomiting and poor suckling. Magnetic resonance imaging ( MRI ) revealed a tumor, which located in forth ventricle to cerebellopontine angle, with obstructive hydrocephalus. In blood analysis, there were slightly elevated α-fetoprotein and neuron-specific enolase. She undergone a surgical resection and the ventricle drainage. We confirmed postoperative MRI scan that suggested gross total removal and no evidence of metastatic lesion in the central nerve system. The pathological findings suggested immature teratoma including anaplastic neuroectodermal component and vacuolar cells around nuclear that resembles atypical teratoid/rhabdoid tumor (AT/RT) morphologically, but the immunohistochemical staining of INI-1 was positive. There were no findings of other germ cell tumors. One month after the operation, she had dissemination at brain stem and spinal cord. She died of tumor progression two months after the surgery. In pathological autopsy, it was revealed that this tumor was primary intracranial immature teratoma. We report an aggressive immature teratoma with anaplastic component and include segment like AT/RT.