Abstract
Background Plasma from HIV-1 seropositive individuals show a range of specificities from variant specific to broad cross-neutralizing. The plasma also show different kinetics of neutralization which may be linked to their specificity. The properties may be a consequence of being a polyclonal mixture of antibodies. Isolating monoclonal antibodies from these people would help to resolve these issues.
Highlights
Plasma from HIV-1 seropositive individuals show a range of specificities from variant specific to broad cross-neutralizing
Plasma from patients infected with either HIV-1 subtype C or CRF02_AG and attending the HIV clinic in Antwerp were screened in PBMC neutralization assays
The neutralizing properties of the monoclonal antibodies do not reflect those of the plasma from the original donors
Summary
Address: 1Institute of Tropical Medicine, Antwerp, Flanders, Belgium, 2Biomedical Primate Research Centre, Rijswijk, Netherlands, 3Institute for Research in Biomedicine, Bellinzona, Switzerland and 4University College London, London, UK. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P392 doi:10.1186/1742-4690-6-S3-P392. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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