Abstract
Background Identification of the transmitted/founder virus in HIV-1 infection allows a unique opportunity to explore the earliest processes of immune pressure and escape. Through single genome amplification (SGA), we can identify the transmitted envelope (env), characterize the diversity of plasma viral quasispecies at subsequent time points, and characterize neutralizing antibody (Nab) responses.
Highlights
Identification of the transmitted/founder virus in HIV-1 infection allows a unique opportunity to explore the earliest processes of immune pressure and escape
In CH077, we observe that the earliest neutralizing antibody (Nab) likely recognizes a conformational epitope involving V2 and C2
Elicitation of Nab against conformational epitopes may be a common theme in early HIV-1 infection
Summary
Neutralizing antibody responses against conformational envelope epitopes in early HIV-1 infection. Address: 1Medicine, University of Alabama at Birmingham, AL, USA, Birmingham, USA, 2National Cancer Institute-Frederick, Frederick, USA and 3National Institutes of Health, Bethesda, MD, USA. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P71 doi:10.1186/1742-4690-6-S3-P71. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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