Abstract
Background While neutralizing antibodies should limit the replication of HIV/SIV in the infected individual, autologous neutralizing antibodies are generated too late following HIV/SIV infection to contribute to early virus control. The present study addresses whether vaccine-induced immune responses accelerate the generation of autologous neutralizing antibodies following SIV challenge in rhesus monkeys, and if this antibody response shapes viral sequence evolution.
Highlights
While neutralizing antibodies should limit the replication of HIV/SIV in the infected individual, autologous neutralizing antibodies are generated too late following HIV/SIV infection to contribute to early virus control
AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
The present study addresses whether vaccine-induced immune responses accelerate the generation of autologous neutralizing antibodies following SIV challenge in rhesus monkeys, and if this antibody response shapes viral sequence evolution
Summary
Kinetics of antibody neutralization and viral evolution following envelope vaccination in SIV-infected rhesus monkeys. Address: Viral Pathogenesis, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P69 doi:10.1186/1742-4690-6-S3-P69. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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