Abstract
Results There were 1,120 case subjects and 41,409 control subjects in the final analysis. There was a significant reduction of CVD development for consuming ephedrarelated CHP (OR=0.183, p<0.001). Only three items (Xiao Xu Ming Shang OR=2.212, p<0.001; Gui Qi Shao Yao Zhi Mu Shang OR=1.701, p<0.001; She Gan Ma Huang Shang OR=1.441, p=0.006) out of a total of 24 ephedra-related CHP were associated with the risk of CVD development. No statistically linear dose-response relationship was observed with the prescribed dose of ephedra.
Highlights
After reviewing some adverse events, such as cardiovascular disease, regarding the use of ephedra-containing dietary supplements, the Food and Drug Administration banned the sale of ephedra products on April 12, 2004
This paper examined the association between prescribed ephedra-containing Chinese herbal products (CHP) and cardiovascular disease by using the population-based database in Taiwan
There was a significant reduction of cardiovascular disease (CVD) development for consuming ephedrarelated CHP (OR=0.183, p
Summary
After reviewing some adverse events, such as cardiovascular disease, regarding the use of ephedra-containing dietary supplements, the Food and Drug Administration banned the sale of ephedra products on April 12, 2004. According to standard prescriptions recommended by the Committee on Chinese Medicine and Pharmacy in Taiwan, ephedra is still a popular ingredient of many Chinese herbal formulas. This paper examined the association between prescribed ephedra-containing Chinese herbal products (CHP) and cardiovascular disease by using the population-based database in Taiwan
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