Abstract
Abstract Background: Bipolar disorder (BD) is a debilitating syndrome that is often undiagnosed and undertreated. Population surveys show that persons with BD often self-medicate with complementary and alternative medicine (CAM) or integrative therapies in spite of limited research evidence supporting their use. To date, no review has focused specifically on nonconventional treatments of BD. Objectives: The study objectives were to present a review of nonconventional (complementary and integrative) interventions examined in clinical trials on BD, and to offer provisional guidelines for the judicious integrative use of CAM in the management of BD. Methods: PubMed, CINAHL,® Web of Science, and Cochrane Library databases were searched for human clinical trials in English during mid-2010 using Bipolar Disorder and CAM therapy and CAM medicine search terms. Effect sizes (Cohen's d) were also calculated where data were available. Results: Several positive high-quality studies on nutrients in combination with co...
Highlights
Bipolar Disorder (BD) is a debilitating syndrome that is often undiagnosed and under-treated
Current evidence supports the integrative treatment of BD using combinations of mood stabilizers and select nutrients
Other CAM or integrative modalities used to treat BD have not been adequately explored to date, some early findings are promising
Summary
Bipolar Disorder (BD) is a debilitating syndrome that is often undiagnosed and under-treated. Population surveys show that persons with BD often self-medicate with complementary, alternative medicine (CAM) or integrative therapies in spite of limited research evidence supporting their use. To date no review has focused on non-conventional treatments for BD. Our objective was to present a comprehensive review of non-conventional (complementary and integrative) interventions examined in clinical trials on BD, and to offer provisional guidelines for the judicious integrative use of CAM in the management of BD
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