Abstract
P04-06. Evolution of an anti-MPER gp41 antibody response that mediates broad HIV-1 cross-neutralization
Highlights
The membrane proximal external region (MPER) of the HIV-1 envelope is recognized by three of the few broadly cross-neutralizing antibodies described so far
Multiple plasma samples from participant CAP206 from pre-seroconversion to 3 years post-infection were tested for heterologous neutralization against 42 viruses from various subtypes and HIV-2/HIV-1 MPER chimeric viruses
Anti-MPER antibodies were depleted from plasma by adsorption onto MPER-peptide-coated beads and tested in anti-MPER ELISA and neutralization assays
Summary
Evolution of an anti-MPER gp antibody response that mediates broad HIV-1 cross-neutralization. Address: 1National Institute for Communicable Diseases, Johannesburg, South Africa, 2Institute of Infectious Disease and Molecular Medicine, UCT, Cape Town, South Africa and 3CAPRISA, UKZN, Durban, South Africa. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P34 doi:10.1186/1742-4690-6-S3-P34. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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