Abstract
Two-day-old lambs were inoculated with transformed sheep fetal (SF) cells replicating Feline sarcoma virus (FeSV), or cell-free FeSV derived from FeSV transformed SF cells. Some received autochthonous transformed SF cells replicating FeSV and others, allogeneic transformed SF cells and/or cell-free virus. Undifferentiated sarcomas occurred at every inoculation site. Tumors were usually characterized by a short latent period (4–6 days) rapid growth to peak size of 2–8 cm in maximum dimension (10–15 days) and rapid regression (21–28 days in most lambs). Variations in sizes and duration of tumors were seen in some lambs being noted even in dizygotic twins given similar inocula. Cell-free FeSV was as effective in tumor induction as were transformed allogeneic and autochthonous SF cells replicating virus. Lymphocytic infiltrations were consistently observed in all regressive tumors and regression was coincident with development of cytotoxic complement-dependent antibody and tumor associated transplantation antigen.
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