Abstract
P028 - Expression of Angiopoietin-like 4 Fibrinogen-Like Domain (cANGPTL4) increases risk of brain metastases in women with breast cancer
Highlights
Breast cancer is a leading cause of cancer death in women [1]
In this study, we showed that a higher expression of Angiopoietinlike 4 Fibrinogen-Like Domain was associated with an increased risk of brain metastases in women with breast cancer
Using an experimental murine model of breast cancer brain metastases, we investigated the role of each cleaved fragment of Angiopoietin-like 4 (ANGPTL4) in the occurrence of brain metastases
Summary
Ten to 35% of patients with breast cancer will develop metastases with a median survival of up to 34.4 months [2]. Brain metastases occur in the progression of metastatic breast cancer in 15 to 40% cases [3], with a median survival of less than 15 months [4], challenging daily practice in oncology. The mechanisms by which cancer cells permeabilize and cross the BBB to form brain metastases remain to be deciphered. Brain metastases challenge daily clinical practice, and the mechanisms by which cancer cells cross the blood-brain barrier remain largely undeciphered. We studied the link between ANGPTL4 and the risk of brain metastasis in cancer patients
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