Abstract
In our multicenter, prospective study; we aimed to investigate the impact of testosterone deficiency on cognitive functions in prostate cancer patients receiving hormone therapy. A total of 30 metastatic prostate cancer patients receiving hormonal therapy were enrolled in the study. Demographic data such as age, smoking, comorbidity, prostate biopsy pathology, PSA level and testosterone levels were recorded. Patients with a diagnosis of dementia or a history of brain surgery were excluded from the study. Four different tests were used to evaluate cognitive functions:Symbol Digit Modalities Test (SDMT) for person's attention and speed of processing, California Verbal Learning Test Edition-2 (CVLT-II) for verbal memory, Brief Visuospatial Memory Test - Revised (BVMT-R) for visuospatial learning and memory abilities, and Trail Making Test (TMT) for attention and working memory. Depressive symptoms were measured using the Beck Depression Inventory. Cognitive functions were recorded before the hormonal therapy (basal cognitive assessment), third and sixth months of the hormonal therapy.
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