Abstract
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PMPreeti S. Ajapuje¹, Parikshit S. Prayag¹, Bharat D. Purandare¹, Sampada A. Patwardhan², Shweta P. Panchakshari¹, Rajeev N. Soman¹Department of Infectious Diseases, Deenanath Mangeshkar Hospital, Pune 2Department of Microbiology, Deenanath Mangeshkar Hospital, PuneObjectivesTo study the susceptibility patterns in blood isolates of Candida parapsilosis at a tertiary care center.MethodsThis was a retrospective observational study of nine cases of candidemia due to C. Parapsilosis over a period of 1 year. Data were collected using the hospital’s electronic health records. Species identification was done using Matrix-Assisted Laser Desorption and Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS) (Bruker Biotyper Sirius-Bruker Daltonics, Bremen, Germany). Antifungal susceptibility was performed by broth microdilution method using Sensititre™ YeastOne™ YO1O AST Plates (Thermofisher Scientific, USA).ResultsAll patients with C. parapsilosis bloodstream infection had central venous access and all patients had received broad-spectrum antibiotics at the time of developing candidemia. Four patients developed C. parapsilosis candidemia in the post coronavirus disease 2019 (COVID 19) setting. Out of the 9 isolates, 7 (77.7%) were resistant to fluconazole, 2 were resistant to voriconazole and posaconazole, and 1 isolate was resistant to amphotericin. A total of 4/9 patients were started on fluconazole prior to antifungal susceptibility testing; 3 of these needed to be switched to an echinocandin due to fluconazole resistance.ConclusionFluconazole resistance in this study was seen in 7/9 (77.7%) isolates which is more than what has been previously described for C. parapsilosis. This makes fluconazole a poor choice for the treatment of C. parapsilosis in our institute. These findings may have an implication in the selection or de-escalation of antifungal treatment for C. parapsilosis.
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