Abstract
Aims & Objectives: The objective of this study was to assess the pattern, risk factors and outcome of Acute Kidney Injury in critically ill pediatrics patients admitted to Tikur Anbessa Specialized Hospital (TASH) in Addis Ababa University Department of Pediatrics and Child Health. . Methods: A prospective cross sectional observational study was conducted on critically ill patients admitted to pediatrics emergency and PICU of TASH from April 2018 to August 2018. The Kidney Disease Improving Global Outcome (KDIGO) definition was used to diagnose and stage AKI. Results: Of the 198 patients admitted to the PICU and pediatrics emergency resuscitation unit 36 patients (18.2%) developed AKI. Seven patients (19.4%) were classified as stage 1, 19 patients (52.8%) as stage 2 and 10 patients (27.8%) were stage 3. Six patients (16.7%) required dialysis. The independent risk factors for development of AKI were severe sepsis and septic shock. Patients with AKI had significantly longer PICU stay (11 days vs 6 days, p = 0.006) and higher mortality (38.9% vs 9.3%). Conclusions: AKI is common in critically ill patients especially those with severe sepsis and septic shock. Patients with AKI had longer PICU stay and the risk of hospital mortality was 6 times higher for children with AKI.
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