Abstract
Coenzyme Q10 is a naturally occurring substance and essential element of the mitochondrial electron transport chain. There has been a recent interest in the role that mitochondria may play in migraine pathogenesis. If indeed migraine results from mitochondrial dysfunction, then coenzyme Q10 could be used as a successful migraine preventive therapy. Abnormal mitochondrial function translates into high intracellular penetration of Ca(2+), excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering migraine mechanisms. The objective of this investigation was to confirm the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches.
Highlights
Coenzyme Q10 is a naturally occurring substance and essential element of the mitochondrial electron transport chain
If migraine results from mitochondrial dysfunction, coenzyme Q10 could be used as a successful migraine preventive therapy
Materials and methods We selected from the Headache Center of the “Istituto Clinico Città di Brescia” a population of 40 patients aged between 18 and 65 years, suffering from migraine without aura with a headache frequency between 3 to 6 crises/ month (4 to 12 days with headache/month), not assuming other migraine preventive therapy
Summary
Pilot study on the use of coenzyme Q10 in a group of patients with episodic migraine without aura. Giorgio Dalla Volta*, Daniela Carli, Paola Zavarise, Gaelle Ngonga, Stefano Vollaro. From Abstracts from the 1st Joint ANIRCEF-SISC Congress Rome, Italy. From Abstracts from the 1st Joint ANIRCEF-SISC Congress Rome, Italy. 29-31 October 2015
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
