P02-Brain-mapping on animal models

Abstract

Electroencephalography (EEG) is a method that reflects the electrical activity of the brain. Changes in electrical activity can be reflected also in 2D or 3D maps Measurements of brain electrical activity in animals are essential for the validation of the pharmaco-effect on the brain. The translational approach using similar methods for quantitative EEG needs to be analysed in animal models. We measured nine brains of Wistar rats using dental X-ray. We compared these values with the model from atlas (3d Brain Atlas Reconstructor). To validate the brain model, we used the descriptive statistics. Wistar’s and human EEG were mapped using spherical spline curves and 3D spline curves. Both methods have the lowest error values – root mean squared error (RMS). By validating the model, we obtained the following statistical values: maximal upper deviation 1.466 mm, maximal lower deviation −1.660 mm, average deviation 0.091/0.300 mm, standard deviation 0.239 mm. Created module was implemented in MATLAB R2015a and allows you to record different kind of brain models. The way to evaluate these records should be comparable to that of EEG on humans. We have validated the rat brain model. Implemented module can be used for further studies in animals and humans.