Abstract

BackgroundMajor depression and post-traumatic stress disorder (PTSD) are commonly associated with coronary heart disease (CHD) as well as hyperhomocysteinemia and hypercholesterolemia. Personality types A and D are claimed to be risk factors for CHD.AimTo evaluate relations between risky personality types, cholesterol and homocystein serum levels in patients with major depression compared to PTSD patients with and without depression.Subjects and methodsPersonality types A and D, cholesterol and homocysteine level were assessed in 40 patients with major depression and 40 male PTSD patients with and without depression.ResultsHypercholesterolemia and hyperhomocysteinemia were found more frequently in patients with major depression and PTSD patients with depression than in PTSD without depression. Personality type D (tendency to experience negative emotions and social inhibition) was more frequent among PTSD patients compared to patients with depression, while there was no difference in personality A type (competitiveness, time urgency, aggressiveness and hostility) distribution.ConclusionHypercholesterolemia and hyperhomocysteinemia may be useful clinical markers related to specific treatment options in patients with major depression as well as in PTSD patients.

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