P02.20: Prenatal diagnosis of enormous intra and extracranial teratoma

Abstract

Intracranial tumors diagnosed in utero belong to the extremely rare pathologies of the fetus. The teratomas are the most frequent group of inherited intracranial neoplasms which arise from the primary germ cell. Teratomas are composed of elements derived from one, two or three embryonal layers. The present study describes a case report of the massive intracranial fetal teratoma, with involvement of the orbit. The tumor was diagnosed at 34th week of pregnancy, in patient admitted to the hospital with suspicion of encephalocoele, polyhydramnios and signs of threatened preterm labor. Ultrasound examination revealed increased biparietal diameter and the presence of intracranial mass of mixed cystic and solid appearance. Anatomy of the central nervous system was distorted by the tumor. Examination also revealed a large solid structure protruding from the right orbit. The patient was delivered by Cesarean section and the female infant 2750 g was born. Further examinations (including magnetic resonance imaging and ultrasonography) performed after birth confirmed preliminary prenatal diagnosis and the tumor was found to be non-operative; the general prognosis for the neurophisological development was poor. The infant died in the fifth day of life due to cardiopulmonary collapse. Histologically the tumor was classified as a immature teratoma.