Abstract

There is limited data on the effect of depression on inflammatory bowel disease (IBD)-related hospitalizations. This cross-sectional study aims to evaluate the effect of depression on pediatric IBD-related hospitalization, with primary focus on length of hospital stay (LOS). Secondary goals were to evaluate if patients with depression are at higher risk for undergoing additional imaging and procedures. [SV1] Data was extracted from the 2012 Kids Inpatient Database (KID), the largest nationally representative pediatric inpatient cross-sectional database in the United States. Hospitalizations for patients <21 years with a primary diagnosis Crohn’s Disease (CD) or Ulcerative Colitis (UC) by ICD-9 code were included. Multivariate logistic regression was used to predict long LOS controlling for patient- and hospital-level variables, as well as potential disease confounders. For primary IBD-related hospitalizations (N=8,169), depression is associated with prolonged LOS (odds ratio [OR] 1.48; 95% confidence interval [CI] 1.19-1.82) and TPN use (OR 1.55; 95% CI 1.10-2.19). However, it is not associated with increased likelihood of surgery (OR 1.00; 95% CI 0.75-1.34), endoscopy (OR 0.90; 95% CI 0.73-1.11), or additional imaging (OR 0.99 95% CI 0.46-2.09). Depression is associated with prolonged length of hospital stay in pediatric patients with IBD, even when controlling for gastrointestinal disease severity. Future research evaluating the efficacy of standardized outpatient depression screening and early intervention may be beneficial to improving inpatient outcomes in this population.

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