Abstract

Acute Generalized Exanthematous Pustulosis (AGEP) is a rare skin rash that begins on the face or intertriginous areas and spreads rapidly, with numerous sterile pustules seen on swollen erythema. First described as a subset of pustular psoriasis in a patient with no prior psoriasis history, AGEP typically has acute onset, with an incidence of about one in five million, elicited by drugs about 90% of the time. Most patients also have fevers and leukocytosis, plus mild eosinophilia. Histopathology shows spongiform subcorneal and/or intraepidermal pustule. Skin symptoms usually resolve within two weeks without treatment.

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