Abstract
Staphylococcus aureus including MRSA (15.3%), Klebsiella spp. (6.8%), Haemophilus spp. (6.1%), and Enterobacter spp. (5.0%). Acinetobacterspp. and MRSA were significantly associated with late-onset VAP while Haemophilus spp. and Streptococcus pneumoniae were significantly associated with early-onset VAP. Acinetobacter spp. was the only pathogen associated with recurrent VAP and its incidence showed a significant increasing trend during the study period. Acinetobacter spp. was significantly associated with prolonged ventilation, sedation, and nasogastric intubation.
Highlights
The guidelines for initial empiric antimicrobial therapy for ventilator-associated pneumonia (VAP) are highly dependent on the type of causative pathogen and the time of diagnosis
A total of 457 pathogens were identified during the study; 380 (83.2%) were associated with primary VAP and 77 (16.8%) were associated with recurrent VAP
Acinetobacterspp. and MRSA were significantly associated with late-onset VAP while Haemophilus spp. and Streptococcus pneumoniae were significantly associated with early-onset VAP
Summary
The guidelines for initial empiric antimicrobial therapy for ventilator-associated pneumonia (VAP) are highly dependent on the type of causative pathogen and the time of diagnosis. From 2nd International Conference on Prevention and Infection Control (ICPIC 2013) Geneva, Switzerland. Introduction The guidelines for initial empiric antimicrobial therapy for ventilator-associated pneumonia (VAP) are highly dependent on the type of causative pathogen and the time of diagnosis. Objectives The objective was to examine the microbial causes of VAP and describe any variability by the timing of VAP onset and over-time.
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