P-0127 Study on 34 Cases with Primary Malignant Gastric Lymphoma

Abstract

ABSTRACT Introduction Primary malignant gastrointestinal lymphoma accounts for 1-4% of malignant gastrointestinal tumors and approx. 10% of all malignant lymphomas, while primary malignant gastric lymphoma accounts for the highest percentage (65%) of primary malignant gastrointestinal lymphomas. Herein, we report the results of our study on 34 patients with primary malignant gastric lymphoma. Methods In the case that gastric malignant lymphoma was diagnosed in our hospital by 1988 from 2010, we find 34 cases of primary gastric malignant lymphoma. So we reviewed and reported about age, gender, kind of therapy, clinical income and prognosis. Results The male/female ratio was 22:13, and the median age was 60 years old. They were diagnosed based on endoscopic examination (31 patients), resected specimen (2), and no clear data (1). The tissue type was indolent lymphoma (8 patients), aggressive lymphoma (21), and unclear (5), and the number of cases with DLBCL was the highest. As the clinical disease stage, Lugano international disease stage classification I was confirmed in 16 patients, II in 9, IIE in 1, IV in 4, and unclear in 4. For the treatment, single surgical treatment was provided to 4 patients, surgery+chemotherapy to 15, single chemotherapy to 9, surgery+chemotherapy+radiotherapy to 1, chemotherapy+radiotherapy to 1, sterile filtration to 1, and 3 were untreated. As for the therapeutic effect, CR was confirmed in 23 patients, PR in 2, NC/PD in 6, and unclear in 3. Conclusion For malignant gastrointestinal lymphoma, surgery has traditionally been performed as the first-line treatment in the limited stage, and thus surgical treatment was performed for many of the subjects of our study who were diagnosed in the 1980s to 90s. In recent years, however, favorable prognoses have been observed because of the increasing usefulness of chemotherapy, radiotherapy, and sterile filtration for MALT lymphoma, and the general selection of gastric conservation therapy. The benefits of surgical treatment include decreased tumor amount by resection of local and regional lymph nodes, and more accurate diagnosis of the disease stage. However, we consider that the disadvantages of the majority of the recent therapies can be avoided by performing endoscopic examination and improving diagnostic imaging.