Abstract
Purpose The reactive stromal phenotype in the prostate is mechanistically important for understanding prostate cancer progression and may be a target for prevention. We mimicked the interaction of endocrine, paracrine, and immune factors on induced androgen metabolism in prostate stroma by coculturing human primary prostate stromal cells and LAPC-4 prostatic adenocarcinoma cells. The aim of the study was to use this model to investigate dose dependent effects of hop-derived polyphenols xanthohumol (Xan), isoxanthohumol (iXan), 8prenylnaringenin (8-PN) and structurally-related compounds quercetin (Que), naringenin (Nar), and 6dimethylallylnaringenin (6-DMAN) on PSA secretion.
Highlights
The reactive stromal phenotype in the prostate is mechanistically important for understanding prostate cancer progression and may be a target for prevention
We mimicked the interaction of endocrine, paracrine, and immune factors on induced androgen metabolism in prostate stroma by coculturing human primary prostate stromal cells and LAPC-4 prostatic adenocarcinoma cells
Conversion of DHEA (D) by the reactive stroma to androgens following TGF-beta (T) stimulation was assessed by induced PSA secretion in LAPC-4 cells
Summary
The reactive stromal phenotype in the prostate is mechanistically important for understanding prostate cancer progression and may be a target for prevention. The aim of the study was to use this model to investigate dose dependent effects of hop-derived polyphenols xanthohumol (Xan), isoxanthohumol (iXan), 8prenylnaringenin (8-PN) and structurally-related compounds quercetin (Que), naringenin (Nar), and 6dimethylallylnaringenin (6-DMAN) on PSA secretion
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