Abstract
Purpose Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA). Having previously demonstrated that curcuminoid-only and essential oil-only fractions of turmeric prevent joint destruction in an animal model of RA, we hypothesized that synoviocyte PTHrP production could be one signaling pathway targeted by turmeric (Curcuma longa L.) in RA.
Highlights
Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA)
Curcuminoids and essential oils of turmeric are both potent suppressors of cytokine-stimualted PTHrP secretion from human rheumatoid synoviocytes
When coupled with our previous in vivo studies demonstrating protective effects of both extracts in an animal model of rheumatoid arthritis, these findings suggest that both secondary metabolites of turmeric may have medicinal effects in the treatment of rheumatoid arthritis
Summary
Turmeric inhibits parathyroid hormonerelated protein (PTHrP) secretion from human rheumatoid synoviocytes. From International Research Congress on Integrative Medicine and Health 2012 Portland, Oregon, USA. Purpose Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA). Having previously demonstrated that curcuminoid-only and essential oil-only fractions of turmeric prevent joint destruction in an animal model of RA, we hypothesized that synoviocyte PTHrP production could be one signaling pathway targeted by turmeric (Curcuma longa L.) in RA
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