Abstract
Methods The experiments were approved by the institution ethics committee under protocol n. 23080.006492/2011-61. Male Swiss mice were randomly divided in the following groups (n=8): naive, control (not treated), Off (LED device turned off), LEDT 1, 3, 5, 7 and 9 (treated with energy densities of 1 through 9 J/cm2). Control, Off and LEDT groups were submitted to a 5mm longitudinal PI (right hindpaw) under anesthesia (1-2% isoflurane). Mechanical hypersensitivity (MH) was assessed as withdrawal frequency percentage to 10 presentations of a 0.4g von Frey filament. Evaluations were conducted before and on day 1 through 5 after PI. LEDT (MOLIMEDpen device; 950 nm wavelength, 80 mW/cm2 irradiance; 1 to 9 J/cm2 energy density) was applied directly to the skin of the incision site.
Highlights
Evaluate the antihypersensitivity effect of Light Emitting Diode Therapy (LEDT) in the plantar incision (PI) model in mice as well as investigate the possible involvement of the opioid system in this effect
Light-emitting diode therapy reduces mechanical hypersensitivity induced by plantar incision model in mice via opioid mechanism
Male Swiss mice were randomly divided in the following groups (n=8): naive, control, Off (LED device turned off), LEDT 1, 3, 5, 7 and 9
Summary
Purpose Evaluate the antihypersensitivity effect of Light Emitting Diode Therapy (LEDT) in the plantar incision (PI) model in mice as well as investigate the possible involvement of the opioid system in this effect
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