Abstract
Methods This study was conducted as an open, cross-sectional, single-center, comparative clinical study. The IRBapproved protocol of this study is in the process of being registered with the NIH (clinicaltrials.gov). The sample size was a total of 72 participants who had no past illness or had taken any concomitant medications. Participants were divided into two groups of middle aged (45-64) and elderly (over 65) participants. Each volunteer was given informed consent for checking cognition (Modified MMSE, ADAS-cog) and cardiac function (HRV). Blood and urine samples were collected to analyze genomic, proteomic, and metabolomic markers related to cognition (APOe4, type-3 metabotropic glutamate R) and cardiac function (CRP, cardiac troponin T).
Highlights
Purpose the aging process appears to be generally characterized, much attention has been paid to the specific target molecules to discover clinical surrogate markers of senescence
The present study is to investigate the phenotypic profile of cognitive decline and functional cardiac senescence in healthy middle aged and elderly volunteers
There was a significant difference between the two groups in terms of ADAS-cog total score (3.3 points, p = 0.002) and modified-MMSE, immediate and delayed recall, by 1 point (p = 0.047)
Summary
Assessing cognitive decline and cardiac senescence in middle aged and elderly volunteers: implications for herbal medicine utilization. From International Research Congress on Integrative Medicine and Health 2012 Portland, Oregon, USA. Purpose the aging process appears to be generally characterized, much attention has been paid to the specific target molecules to discover clinical surrogate markers of senescence. The present study is to investigate the phenotypic profile of cognitive decline and functional cardiac senescence in healthy middle aged and elderly volunteers
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