Abstract
Results We found that at low doses Huang Qin induced cytotoxicity (1 μg/ml), but at high doses, 50-300 μg/ml, the same herb induced cell proliferation. Chuan Bei Mu exhibited a similar biphasic response with cytoxicity at 1-200 μg/ml but proliferation at 400 μg/ml. Data on Lian Qiao was scattered but the herb induced cytotoxicity at low doses from 1-10 μg/ml and less significantly at high doses. Bai Zhi was the only herb that did not induce cytotoxicity in endometrial cancer cells.
Highlights
We shortlisted four commonly-used herbs from the Chinese Materia Medica, including Lian Qiao (Forsythiae Fructus), Chuan Bei Mu (Fritillariae cirrhosae Bulbus), Bai Zhi (Angelicae dahuricae Radix) and Huang Qin (Scutellariae Radix) due to suggestions in classical writings that they could possess antitumor properties
Cells were incubated for 24 hours in varying concentrations (1-500 μg/ml)
We found that at low doses Huang Qin induced cytotoxicity (1 μg/ml), but at high doses, 50-300 μg/ml, the same herb induced cell proliferation
Summary
Purpose We shortlisted four commonly-used herbs from the Chinese Materia Medica, including Lian Qiao (Forsythiae Fructus), Chuan Bei Mu (Fritillariae cirrhosae Bulbus), Bai Zhi (Angelicae dahuricae Radix) and Huang Qin (Scutellariae Radix) due to suggestions in classical writings that they could possess antitumor properties
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