Abstract
Methods We performed BV pharmacopuncture therapy with different concentrations on neuropathic pain in a rat model on the 7th day after ligating the L5 nerve as suggested by Kim and Chung. Rats were divided into a control group (treated with normal saline), experimental group I (treated with constantly increased BV concentration, from 1.67×10mg/kg to 8.35×10mg/kg, total 3.22×10mg), and experimental group II (treated fixed high concentration, 3.58×10mg/kg, total 3.22×10mg). BV pharmacopuncture was injected to Huantiao (GB30) every other day for 18 days. To identify any therapeutic effect, foot withdrawal threshold to mechanical and thermal stimulation, nerve conduction velocity (NCV), and c-Fos immunological reactivity in the dorsal horn of the spinal cord were analyzed.
Highlights
The purpose was to examine the effect of bee venom (BV) pharmacopuncture therapy with different concentrations on neuropathic pain in a rat model
Rats were divided into a control group, experimental group I, and experimental group II
BV pharmacopuncture was injected to Huantiao (GB30) every other day for 18 days
Summary
Purpose The purpose was to examine the effect of bee venom (BV) pharmacopuncture therapy with different concentrations on neuropathic pain in a rat model
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