P0097 ALK rearrangements in turkish patients with lung adenocarcinoma

Abstract

<h3>Background</h3> We aimed to establish the frequency of ALK translocation in lung adenocarcinomas at a population level. <h3>Methods</h3> Between 2011 and 2013, 157 paraffin embedded tumour tissue samples were collected by our hospitals. Forty patients from this group were also scanned for EGFR mutations. FISH technique was used on paraffin embedded tissues, which were cut 4 microns thick. Vysis ALK Breakapart FISH probe kit was used to detect rearrangement of ALK gene. <h3>Findings</h3> Twenty patients (12.7%) were positive for ALK rearrangement. ALK-positive patients were younger than ALK-negative patients. <h3>Interpretation</h3> Our study is the first to investigate the ALK status of lung cancers in Turkish patients.