P0076 Percutaneous cryoablation for stage iv lung cancer: A retrospective analysis

Abstract

Background The aim of this study was to investigate the therapeutic effect of cryoablation treatment and palliative treatment in stage IV lung cancer. Methods Fifty-four patients with intrapulmonary and extrapulmonary tumours were enrolled into the study. 31 patients received cryoablation treatment and 23 patients had palliative treatment (no cryoablation). Both the safety of the procedure and overall survival (OS) for stage IV lung cancer were assessed during a 6.5-year follow-up period. The OS of patients in both groups and the effects of treatment timing and frequency were compared. Findings The OS in the cryoablation group was significantly longer than in the palliative group (median OS: 14 months versus 7 months, p = 0.0009). The OS of those who received delayed cryoablation treatment was longer than that observed for those who received timely treatment (median OS: 18.5 months versus 10 months, p = 0.0485), but this was not observed in those who received palliative treatment (median OS: 7 months versus 7.5 months, p = 0.9814). Multiple treatments compared with single treatments played an important part in improving the OS of patients who received cryoablation treatment (median OS: 18 months versus 14 months, p = 0.0376). Interpretation There was a significant difference between cryoablation and palliative treatment in terms of OS. In addition, multiple cryoablation treatments may have an advantage over single treatments.