P0070 E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions

Abstract

Background Loss of E-cadherin is a critical step for development and progression of malignant tumours. CD10, a marker of non-neoplastic and neoplastic endometrial stroma, is associated with aggressiveness of many epithelial malignancies. We sought to evaluate the expression and correlation of E-cadherin and CD10 in endometrial lesions and their possible role in differentiating atypical endometrial hyperplasia from endometrial carcinoma. The association of E-cadherin and CD10 expression with clinicopathological parameters of endometrial carcinoma was also investigated. Methods Fifty-four patients were enrolled in this study, including 28 with endometrial carcinomas, 19 with endometrial hyperplasia, and seven with normal endometrial changes. We evaluated the expression of E-cadherin and CD10 by immunohistochemistry using the streptavidin–biotin technique. Findings There was a strong association between malignant change of endometrial glands and membranocytoplasmic localisation of E-cadherin ( p p p p p p p p Interpretation Although expression of E-cadherin and CD10 in endometrial lesions is not correlated, reduced expression of both molecules could be critical for progression and invasion of endometrial carcinoma.