P0063 HPV infection and lymphoma incidence using cervical conisation as a surrogate marker: A Danish nationwide cohort study

Abstract

Background Persistent human papillomavirus (HPV) infection may promote carcinogenesis by hyperactivation of the immune system. We therefore explored the associations between HPV infection and risk of Hodgkin’s and non-Hodgkin lymphoma in a nationwide cohort study using conisation as a surrogate marker. Methods We identified all Danish women who underwent conisation between 1978 and 2011. We computed standardised incidence ratios and 95% confidence interval (CI) for Hodgkin’s and non-Hodgkin lymphomas based on rates of national cancer incidence. Findings Of 87,435 women who underwent conisation (1978–2011), we noted an increased incidence of Hodgkin’s lymphomas (standardised incidence ratio [SIR] 1.48, 95% CI 1.05–2.02), but only a slight increase in incidence for non-Hodgkin lymphoma (SIR 1.10, 95% CI 0.97–1.25). Interpretation HPV infection, as measured by conisation, is associated with an increased risk of lymphoma. This association may be attributable to a chronic immune activation induced by persistent HPV infection or poor clearance of HPV.