P0041 / #511: EVALUATION OF DELIRIUM IN THE PEDIATRIC INTENSIVE CARE UNIT OF HOSPITAL ITALIANO DE BUENOS AIRES. INTERIM ANALYSIS.

Abstract

Aims & Objectives: Delirium is a frequent and serious complication of certain critical illnesses. The goal of this study is to evaluate the incidence of delirium in critically ill patients under invasive mechanical ventilation (IMV) for more than 48 hours and to explore associated risk factors. Methods: An interim analysis of a prospective observational study was performed. All patients who were over six months of age, were admitted to the pediatric intensive care unit (PICU) between October 2018 and December 2019 and required invasive mechanical ventilation (IMV) for more than 48 hours consecutively entered the study. Children were screened for delirium using the pCAM-ICU and psCAM-ICU and were evaluated for 5 consecutive days after extubation. Results: Forty-two children were included up until December 31st, 2019. Two were eliminated from the analysis due to missing data (Figure 1). From the 40 children included, 16 (40%) suffered delirium (Table 1). Most cases of delirium belonged to the hypoactive subtype (81.25%); only 18.75% of delirium episodes were characterized as hyperactive delirium. There was no statistically significant relationship between opioid exposure, days of mechanical ventilation, or probability of mortality score on the development of delirium. Univariate analysis revealed that the occurrence of delirium was significantly associated with benzodiazepine exposure, OR 1.34 (IC 95% 1.04 - 1.74, p = 0.024).Conclusions: The incidence of delirium observed in this cohort so far was similar to that reported in the literature. Benzodiazepine exposure was associated with the development of delirium.