Abstract
I/R injury remained more prominent in DBD grafts as compared to their DCD counterparts. Further, there was greater upregulation of pro-inflammatory ceramides in post-transfusion biopsies in DBD as compared to DCD allografts. Despite decreased inflammation, DCD allografts had significantly higher levels of cell death than DBD grafts, which correlated with the duration of warm ischemia time as well as significantly higher levels of aspartate aminotransferase (AST) in the serum of recipients of DCD livers in the acute posttransplant period. Conclusions: These data suggest that ischemia/reperfusion injury causes a non-inflammatory necrosis in DCD allografts with an appreciable effect on early graft function. The long-term consequences of increased inflammation in DBD allografts and cell death in DCD allografts are unknown and warrant further investigation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
