P0031IS OXIDATIVE STRESS ASSOCIATED WITH TOTAL KIDNEY VOLUME IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE?

Abstract

Abstract Background and Aims Ischemia Modified Albumin (IMA) is a marker of cardiovascular risk factor associated with oxidative stress. In this study, our aim was to determine oxidative stress status in autosomal dominant polycystic kidney disease (ADPKD) and to evaluate its relationship with total renal volume. Method Seventy-two ADPKD (mean age 52 (41-64) years) and 33 healthy controls (mean age 54 (42-62) years) (P= 0.372) were included in the study. Total Oxidant Level (TOS) and Total Antioxidant Level (TAS) were measured using the colorimetric method. Oxidative Stress Index (OSI) was calculated. IMA level was measured by ELISA. Total renal volume was assessed by magnetic resonance imaging. The relationship between oxidative stress, inflammation and renal volume was evaluated by correlation analysis. P values <0.05 were considered significant for statistical analyses. Results Serum IMA level was higher in the patient group (158.46 ng/ml (85.98-246.70)) than in the control group (70.04 ng/ml (50.40-80.02); (P< 0.001). TOS level and OSI rate were significantly higher in the patient group compared to the control group, and TAS level was not different between the two groups (P< 0.001, P< 0.001, P= 0.576, respectively).Correlation analysis was performed between IMA, TAS and TOS levels, OSI rate and kidney volume. IMA level correlated with TOS level and OSI positively (P< 0.001), but there was no correlation between IMA level and TAS level and renal volume (P= 0.550, P= 0.286, respectively). IMA level was negatively correlated with GFR and positively correlated with proteinuria (P= 0.040, P< 0.001, respectively). There was no correlation between total renal volume and IMA, TAS, CRP and proteinuria. The correlation between volume and GFR and TOS level was borderline negative (P= 0.054, P= 0.051, respectively). Conclusion There is an increased level of oxidative stress in ADPKD. Increased IMA level may show oxidative stress in this population. Total renal volume in ADPKD is associated with loss of renal function but not sufficient to show oxidative stress.