P003 Prognosis of Advanced Lung Cancer by Age Groups: A SEER Database Analysis

Abstract

Lung cancer is very common in malignancies, it is the main cause of cancer death. Lung cancer usually occurs in the elderly, and it is late for diagnosis. However, there are few studies on the prognosis of advanced lung cancer by age groups. The purpose of this study is to investigate the effect of age on the prognosis of advanced lung cancer. We extracted the data of lung cancer patients diagnosed stage IV between 2010 and 2014 from the Surveillance, Epidemiology and End Results (SEER) database in which data of patients with unknown age were excluded. We divided the patients into three groups: younger group (age <50 years old), middle-aged group (age between 50-69 years old) and elder group (age >69 years old). Pearson’s χ2 test were used to compare the clinical characteristics of patients in different age groups. We identified the factors associated with overall survival (OS) and lung cancer specific survival (LCSS) by Cox regression. Data of total 120,444 patients were collected including 5,156 in younger group, 55,389 in middle-aged group, 59,899 in elder group. For both OS and LCSS, younger patients were better than middle-aged patients, middle-aged patients were better than elder patients. Besides, the LCSS of middle-aged and elderly patients was significantly lower than OS. In addition, male, white, small cell lung cancer, no radiotherapy, poorly differentiated lung cancer were associated with poor prognosis of lung cancer. The prognosis of advanced lung cancer declined as the increase of age.