P0025 Comparison of the prognostic value of preoperative inflammation-based scores and TNM stage in patients with gastric cancer

Abstract

Background Several inflammation-based scores have been demonstrated to have prognostic value in many types of malignant solid tumours. However, there are no studies elucidating which of these prognostic scores is more suitable in predicting outcomes in patients with gastric cancer undergoing surgery. We aimed to compare the prognostic value of inflammation-based prognostic scores (Glasgow prognostic score [GPS], neutrophil lymphocyte ratio [NLR], platelet lymphocyte ratio [PLR], prognostic nutritional index [PNI] and prognostic index [PI]) and TNM staging in patients undergoing resection of gastric cancer. Methods The inflammation-based prognostic scores were calculated for 207 patients who underwent resection of gastric cancer between June 2005 and September 2011 in the First Affiliated Hospital of Fujian Medical University. Prognostic significance was analysed by univariate and multivariate analyses. Linear trend chi-square test, likelihood ratio chi-square test, and receiver operating characteristics (ROC) were performed to compare the prognostic value of the selected scores and TNM stage. Findings In multivariate analysis, GPS ( p = 0.013), NLR ( p = 0.027), PI ( p = 0.002), TNM stage ( p p Interpretation Our data indicate that preoperative GPS and TNM stage are superior predictors of cancer survival compared with NLP, PLR, PI, and PNI in patients of gastric cancer.