Abstract
Background Verrucous carcinoma (VC) should be considered a distinct clinico-pathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behaviour. The best way to understand the behaviour of these carcinomas is to study them by means of molecular methods, especially in tumour progression tests. Bcl-X is an important anti-apoptotic member of the Bcl-2 family and is a useful marker to determine the aggressiveness of many carcinomas. We have studied the relation between Bcl-X protein and carcinomatous behaviour using immunohistochemical analysis in selected carcinomas of the head and neck region. Methods We studied Bcl-X protein expression in sections of 30 OSCC samples and 10 VC samples and correlated Bcl-X protein expression with tumour differentiation. Findings There was a significant difference in cytoplasmic staining of Bcl-X expression (p Interpretation The significant difference in Bcl-X expression could be helpful in differentiating OSCC and VC from each other.
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