P0012 / #731: ACUTE SYMPTOMATIC SEIZURES FREQUENCY, ETIOLOGY AND OUTCOME OF SEIZURES IN CRITICAL ILL CHILDREN – A STUDY FROM PEDIATRIC INTENSIVE CARE UNIT

Abstract

Aims & Objectives: To determine frequency, etiology and outcome of seizures in critical ill children admitted in intensive care unit at tertiary care hospital. Methods: This was a retrospective descriptive cross-sectional study. Critically ill children with acute symptomatic seizure who were admitted in the Pediatric Intensive care unit (PICU) at Aga Khan University Hospital (AKUH) from January 2016 to December 2018 were included in this study. All information was recorded on a structured form through medical record. The data was analyzed on SPSS version 19. The descriptive statistics frequency and percentage was computed for qualitative. Mean and standard deviation were computed for quantitative variable age and duration of seizures and univariate analysis was done. Results: During the study period, a total 2053 patient were admitted in the PICU. 106 (5 %) had seizure. 63(59.5%) were male. Meningitis 21(20%) and sepsis 21(20%) were diagnosed in children with seizure. 72(68%) were younger than 5 years of age. These seizures lasted for less than 5 minute of duration in 69(65%). Seizure duration of more than 10 minute was observed with high neurological deficit (P 0.001). We did not observed any correlation with electrolyte imbalance, renal failure, need of ventilator support) with duration of seizure and type of seizure (P > 0.005). Conclusions: Infection etiology found to be the most common cause of seizures in critically ill children. Seizures lasting for more than 10 minutes were observed with high neurological deficit in critical ill children. We did not found any relation with mortality with seizure duration.