Abstract

The synthesis of polysubstituted quinolines was accomplished through Friedländer annulation between 2-aminoaryl ketones and different active methylene compounds at room temperature using ball-milling technique in the presence of p-toluenesulfonic acid. The mechanism of the reaction investigated by density functional theory-based modeling is also reported. This study aims at giving insight into the mechanism of the Friedländer reaction in the presence of acid catalysts. Copyright © 2014 John Wiley & Sons, Ltd.

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