P-selectin: an unpredicted factor for deep vein thrombosis after total hip arthroplasty.

Dongquan Shi,Xingquan Xu,Feng Wang,Takahiro Nakamura,Dongyang Chen,Qing Jiang,Zhihong Xu,Jin Dai,Yong Pang,Chen Yao

doi:10.1155/2014/783967

Abstract

Introduction. Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. Materials and Methods. To confirm the association, a total of 91 subjects who received primary total hip arthroplasty using lateral approach performed by one skilled orthopedic surgeon were studied. All the patients were consecutively enrolled at the Center of Diagnosis and Treatment for Joint Diseases, Drum Tower Hospital affiliated to the Medical School of Nanjing University from 2010 to 2012. All the subjects received venography 3–5 days after operation. We measured P-selectin by means of a highly sensitive sandwich ELISA technique and a commercially available test reagent set. Results. No significant association was detected between P-selectin and DVT (all P values > 0.05). ΔsP-selectin was correlated with weight, APTT after operation, history of DVT, and diagnosis of primary disease ( P values were 0.03, 0.03, 0.04, and 0.02, resp.). Conclusion. P-selectin may not be a predicted factor for deep vein thrombosis after total hip arthroplasty.

Highlights

Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA)
Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis [12]
The incidences of diabetes mellitus (DM), HP, and history of DVT are 7.7%, 35.2%, and 7.7%, respectively. 71.4% (5/7) of the patients with history of DVT recurred. 8.8% (8/91) of the patients have the habit of smoking. 42.9% (39/91), 14.3% (13/91), and 27.5% (25/91) of the patients are diagnosed with osteoarthritis (OA), developmental dysplasia of the hip (DDH), and fracture of the hip, respectively. 4 ± 1 days after THA, patients received low limb angiography routinely

Summary

Introduction

Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. ΔsP-selectin was correlated with weight, APTT after operation, history of DVT, and diagnosis of primary disease (P values were 0.03, 0.03, 0.04, and 0.02, resp.). P-selectin may not be a predicted factor for deep vein thrombosis after total hip arthroplasty. It leads to acute pulmonary embolism, a life-threatening disease. There are a lot of biomarkers identified for early diagnosis of or treatment for DVT [4]

Methods

Results

Discussion

Conclusion