Abstract
Chemical investigation on Pilea aquarum subsp. brevicornuta led to the identification of three previously unknown dimeric p-menthene-type monoterpene peroxides, pileadimenthenols A-C (1–3). Their chemical structures and absolute configurations were determined by extensive spectroscopic analyses, X-ray crystal diffraction and ECD calculations. Plausible biogenesis of 1–3 was also proposed. Among the isolates, 2 showed weak cytotoxic activity against HCT-116.
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