P-MD005. Neuroprotective effects of gossypetin in alzheimer's disease: Therapeutic approaches to evaluate the acetylcholinesterase and butyl cholinesterase inhibitory potential

Abstract

Introduction. Phytochemical present in medicinal plants have been used for the treatment of numerous human health complication. Phytochemical can be categorized into different chemical classes including flavonoidal compounds which are well known in the medicine for their anti-cancer, anti-oxidant, anti-aging and anti-inflammatory activity. Gossypetin is pure phytochemical found to be present in the numerous medicinal plants including Hibiscus species. Methods. Biological importances of gossypetin in the treatment of Alzheimer’s disease were studied in the present investigation to know their effectiveness against acetylcholinesterase and butyl cholinesterase (AChE and BuChE) through scientific database analysis of different research work of the scientific fields. Present investigation revealed the biological importance and therapeutic benefit of gossypetin in medicine and other allied health sectors. In order to know the medicinal importance of gossypetin in brain related disorder, here in the present investigation therapeutic benefit of gossypetin on cholinesterase enzymes such as AChE and BuChE were investigated through scientific data analysis of different In-silico research work of the literature. Experimental works have been performed to know the benefit of gossypetin in the medicine. Results. Scientific data analysis of different research work of the literature signified the biological importance of gossypetin in the medicine due to their significant antioxidant potential. Scientific research work data analysis revealed their effectiveness against various form of cancerous disorders such as breast cancer and hepatocellular cancer. Molecular docking study revealed the biological importance of AChE and BuChE enzymes in the brain related disorders. Molecular docking study also signified the probable mode of interaction and binding modes of inhibition of AchE and BuChE enzymes. Research work of different scientific field also revealed the biological importance of hydrophobic interaction in the stability of complex. Conclusions. Present investigation signified the therapeutic benefit of gossypetin for the treatment of Alzheimer's disease through interaction of cholinesterase enzymes.