Abstract
A straightforward synthesis of P-chiral polycyclic 7-phospha-norbornenes via an asymmetric Diels-Alder reaction is presented. The employed starting materials are cheap, easily accessible and of structural diversity facilitating a new flexible route towards differently functionalised P-chiral phosphanes.
Highlights
Chiral compounds are of great importance today and affect almost everybody’s life
A class of such tools that was used in the very beginning of enantioselective catalysis has experienced a comeback recently: the class of P-chiral phosphanes.[2]
One of the main reasons why P-chiral phosphanes have been less applied in asymmetric catalysis than phosphanes having a chiral backbone is their challenging synthesis
Summary
Chiral compounds are of great importance today and affect almost everybody’s life. They are mainly applied in life sciences and drug development, and in the food and fragrance industries, and their efficient and targeted syntheses are no longer solely of academic interest.[1]. A straightforward synthesis of P-chiral polycyclic 7-phosphanorbornenes via an asymmetric Diels–Alder reaction is presented.
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