Abstract

Locally advanced esophageal cancer (EC) remains a disease with poor prognosis, with a 5-year survival of around 40%. In 2012, the CROSS trial was a changing point in the treatment of EC by introducing neoadjuvant (NA) chemoradiotherapy (CRT), with carboplatin/paclitaxel and reduced-dose RT (41.4Gy), as a valid approach, with higher disease-free survival (DFS) and overall survival (OS) than had been seen before. These results had subgroup variations, with better OS in squamous cell carcinoma (SCC) patients when compared to adenocarcinoma (AC).

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