P-92 Autophagy drugs are dynamic regulators of long non-coding RNA expression in colorectal cancer

Abstract

Numerous studies have shown that gene mutation and dysregulation of long non-coding RNAs (lncRNAs) are associated with human cancers including colorectal cancer (CRC). A number of lncRNAs have been structurally and biochemically identified but there was inadequate in-vivo evidence to support their oncogenic activity in cancer. We hypothesized that autophagy, the cellular self-protective mechanism, plays a key role in carcinogenesis by regulating lncRNAs expression in CRC. In this study, our objective was to explore the drug-induced autophagy regulated lncRNAs which may be involved in the carcinogenesis of CRC.