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Abstract
1987) was completed daily each morning. Sleep lab studies were carried out on 7 nights (pre-drug placebo nights 6, 7; drug nights I, 27, 28; post-drug placebo nights 1,7) and included polysomnography, evaluation of subjective sleep quality, subjective and objective awakening quality measured by psychometry. An activity monitor was worn by the patients throughout the 6 weeks to investigate the sleep-wake cycle. Preliminary evaluations demonstrated significant improvement of the anxiety syndrome and the sleep quality during both active compounds, as compared with placebo, with a worsening of symptoms on the I st night of placebo substitution, levelling off until the 7th night. Differential drug effects will be discussed.
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