Abstract
Genetic polymorphisms of the catechol-O-methyltransferase gene (COMT Val158Met) and the serotonin transporter linked promoter region (5-HTTLPR) have been reported to influence the gray matter volumes of amygdala and hippocampus, but the studies have been inconsistent. To elucidate the effects of COMT and 5-HTTLPR on regional gray matter volumes in the same sample of healthy individuals. We conducted a diffeomorphic anatomic registration through exponentiated Lie algebra (DARTEL) voxel-based morphometry (VBM) study of the effects of COMT and 5-HTTLPR polymorphisms and their interaction on the gray matter volumes of 91 healthy controls. A small increase of gray matter volume in right angular gyrus was detected in carriers of the Met allele of COMT, and no main effects of 5-HTTLPR on gray matter volume were detected. The effects of the interaction between COMT and 5-HTTLPR on gray matter volume were large and mainly involved bilateral amygdala and hippocampus. [COMT × 5-HTTLPR effects on gray matter volume]. The effects of the genetic interaction found in this study might explain the relative inconsistency in the results from previous studies, and suggest further research into genetic interactions.
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