P-795 - Resting-state functional magnetic resonance imaging (fMRI) in charles bonnet syndrome

Abstract

Introduction Charles Bonnet syndrome (CBS) is a condition characterized by complex and recurrent visual hallucinations occurring in patients with severe visual loss, in the absence of cognitive or psychiatric disorders. Patients are completely aware of the unrealistic nature of this phenomenon. Previous functional magnetic resonance imaging (fMRI) studies have demonstrated cortical activation during periods of visual hallucinations in patients with CBS pointing to dysfunction in the primary and secondary visual cortices. Objectives/aims To investigate the pattern of visual activation in a patient with CBS by means of resting-state fMRI. Case report/methods We studied the case of a 75-year-old woman with pronounced visual loss secondary to diabetic retinopathy and recurrent visual hallucinations consistent with CBS. The patient underwent an fMRI examination. No convincing periods of visual hallucinations occurred at the time of scanning. A blood oxygen level dependent (BOLD) sequence (TE = 25 ms, TR = 3000 ms, number of repetitions=200, acquisition matrix=64 × 64) was acquired. After spatial pre-processing including realignment, unwarping, and coregistration to high-resolution T1-weighted images by means of statistical parametric mapping (SPM, FIL, London, UK), BOLD images were analysed by using multivariate exploratory linear optimized decomposition into independent components (MELODIC, FSL, FMRIB, Oxford, UK). Results The independent component analysis (ICA) revealed a very extensive visual network, much more pronounced than the usually observed. Conclusion fMRI data analysed by using ICA seem to demonstrate abnormal visual networks in CBS, even at “rest”. This perhaps indicates that there is a sustained state of hyperactivity in the primary and secondary visual cortices in CBS, most probably secondary to deafferentiation.