Abstract
Since 1980 gonadotrophins have been used in assisted reproduction programs to induce multi-follicular growth and in the past decade highly purified human urinary follicle-stimulating hormones (hFSH) have been successfully adopted. Since 1997, a new highly purified urinary hFSH (Fostimon®, IBSA) has been made available in some European countries. Since 2006, Fostimon has been approved in the European Union by means of a Mutual Recognition Procedure. In spite of their efficacy and clinically proven safety, recently recombinant FSH (rFSH) has been proposed as being safer and clinically more effective than hFSH.
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